The present study was carried out using the four seaweeds, Sargassum wightii, Padina tetrastromatica (Phaeophyceae) , Ulva faciata (chlorophyceae) and Gracilaria edulis (Rhodophyceae) which were found to be dominant in the areas of Arockiapuram, Kootapuli, Uvari , Manapad , Punnakayal from the south east coast of India. The seaweeds were analysed for the presence of important Phytochemical constituents. The effect of the different solvent extracts of the seaweeds were also analysed against eight bacterial pathogens isolated from different patient samples. The isolated pathogens were identified by biochemical tests and further confirmed by 16s rDNA sequencing. The study revealed that the antibacterial activity was significantly higher in methanolic extracts of the four dominant seaweeds and it was on par with the standard antibiotics.
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